최근 10년간 국립암센터에서 치료받은 구강 편평상피세포암종 환자의 치료성적 연구
Clinical Outcomes of Oral Squamous Cell Carcinoma Patients Treated in National Cancer Center for Last 10 years
조세형, 김태운, 정한울, 박성원, 박주영, 최성원,
소속 상세정보
조세형 ( Jo Sae-Hyung ) - 국립암센터 구강종양클리닉
김태운 ( Kim Tae-Woon ) - 서울대학교 치의학대학원 구강악안면외과학교실
정한울 ( Choung Han-Ul ) - 서울대학교 치의학대학원 구강악안면외과학교실
박성원 ( Park Sung-Won ) - 국립암센터 구강종양클리닉
박주영 ( Park Joo-Young ) - 국립암센터 구강종양클리닉
최성원 ( Choi Sung-Weon ) - 국립암센터 구강종양클리닉
KMID : 0360120100320060544
Abstract
Purpose: The result of all malignant neoplasms including oral cancer is decided by long-term prognosis. However, until now, there are only a few reports about long-term prognosis of cancer secluded in the oral cavity. So, we investigated all patients that visited our clinic for oral squamous cell carcinoma (SCCa) for the last 10 years. From this survey, we hope to find important factors that influence prognosis of the disease.
Patients and Methods: A retrospective study was performed for patients that visited the oral oncology clinic for oral cancers from Jan. 2001 to Feb. 2010. We selected the patients that were diagnosed with SCCa and received curative treatment. In these patients, we investigated basic epidemiology, smoking history, body mass index, recurrence rate, treatment methods, pathologic data and 5-yr survival rate.
Results: There was a total of 185 patients (115 males, 70 females and mean age : 57.3 years) that visited the oral oncology clinic for oral SCCa. Areas of primary lesion were the tongue (105 cases, 57%), the lower gum (19 cases, 10%), the floor of mouth (16 caess, 8%), the retromolar trigone (12 cases, 6.5%), and the buccal cheek (11 cases, 6%). Other involved areas were the upper gum, the palate, the lip, and the salivary glands ? of 1 case each. The overall 5-year survival rate was 63.7%. The factors that influenced prognosis of the disease were the stage of the disease, status of differentiation, recurrence, metastasis of cervical lymph node and age at diagnosis.
Conclusion: To summarize, the factors that influence prognosis of disease are the stage of the disease, the status of differentiation, recurrence, metastasis of cervical lymph node and age at diagnosis. To point out a current trend, the mean age of patients that developed oral cancer was lower than that of before. Secondly, the prevalence of oral cancer in non-smoker are on the rise. Thus, further studies on etiology and epidemiology should be done.
키워드
Oral squamous cell carcinoma; Prognostic factors
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